Differential vascular effects of aspirin in people with Type 2 diabetes without cardiovascular disease and matched controls without diabetes.
Liv VernstrømE LaugesenE L GroveJ M BaierS GullaksenA-M HvasP L PoulsenKristian Løkke FunckPublished in: Diabetic medicine : a journal of the British Diabetic Association (2019)
Aspirin had a reduced immediate effect on endothelium-dependent vasodilation in participants with diabetes. Both groups had improved endothelial function after 1 week of treatment. Further, the effect of aspirin on endothelial function may be declining during a 24 h dosing interval in people with Type 2 diabetes. (Clinical Trial Registry No: 2016-000515-32).
Keyphrases
- cardiovascular disease
- cardiovascular events
- low dose
- type diabetes
- clinical trial
- antiplatelet therapy
- glycemic control
- nitric oxide
- cardiovascular risk factors
- anti inflammatory drugs
- endothelial cells
- acute coronary syndrome
- coronary artery disease
- open label
- study protocol
- phase ii
- double blind
- adipose tissue
- phase iii
- placebo controlled
- replacement therapy