Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC.

Hao ChenHao CuiWei LiuBo-Wen LiZhen TianYu-Yue ZhaoGuang-Tao Yu

Published in: Oral diseases (2024)

Manganese induces YAP/TAZ phase separation and subsequent ACSL4 activation via YAP/TAZ nuclear translocation, which facilitates ferroptosis of OSCC. Then YAP/TAZ-ACSL4 axis can be used as a potential prognostic predictor of OSCC patients.

Keyphrases

end stage renal disease
cell death
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported outcomes
risk assessment
human health
oxide nanoparticles