Evolution of the p53-MDM2 pathway.

Emma ÅbergFulvio SaccocciaManfred GrabherrWai Ying Josefin OrePer JemthGreta Hultqvist

Published in: BMC evolutionary biology (2017)

The signaling pathway of the TAD and p53/p63/p73BD in p53/p63/p73 and MDM, respectively, dates back to early metazoan time and has since then tightly co-evolved, or disappeared in distinct lineages.

Keyphrases

signaling pathway
pi k akt
epithelial mesenchymal transition
induced apoptosis
oxidative stress
endoplasmic reticulum stress