Nucleos(t)ide analogues for the treatment of chronic hepatitis B: a systematic review with network meta-analysis.

Jinsong Geng HaiNi Bao YaLan ChenLiLi ShiJing GengQing WangHao Yu

Published in: Expert review of anti-infective therapy (2020)

The nucleos(t)ide analogues are all effective for HBeAg seroconversion, HBeAg loss, undetectable HBV DNA, and most are effective for ALT normalization in adults with CHB. RCTs of multi-center, low risk of bias, and long-term follow-up are still needed.

Keyphrases

hepatitis b virus
systematic review
molecular docking
liver failure
structure activity relationship
circulating tumor
single molecule
cell free
combination therapy
replacement therapy