Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making.

Nassim DjebliVincent BuchheitNeil ParrottElena GueriniYumi ClearyStephen FowlerNicolas FreyLi YuFrançois MercierAlex PhippsGeorgina Meneses-Lorente

Published in: European journal of drug metabolism and pharmacokinetics (2021)

The model simulations were used to derive dosing recommendations for co-administering entrectinib with CYP3A4 inhibitors or inducers. PBPK modeling has been used in lieu of clinical studies to enable regulatory decision-making.

Keyphrases

decision making
transcription factor
molecular dynamics