Prophylactic Antibiotic Choice and Deep Infection in Lower Extremity Endoprosthetic Reconstruction: Comparison of Cefazolin, Cefazolin-Vancomycin, and Alternative Regimens.
Katherine S HajduStephen W ChenardAnthony D JudiceJulia C QuirionAleksander P MikaWilliam B GilbertWilliam HefleyDaniel J JohnsonPatty W WrightHakmook KangJennifer L HalpernHerbert S SchwartzGinger E HoltJoshua M LawrenzPublished in: The Journal of the American Academy of Orthopaedic Surgeons (2024)
The addition of perioperative vancomycin to cefazolin in lower extremity endoprosthetic reconstructions was not associated with a lower deep infection rate. Patients who did not receive cefazolin trended toward higher rates of deep infection and revision surgery, although not statistically significant. The most common reason for not receiving cefazolin was a nonanaphylactic penicillin allergy, highlighting the continued practice of foregoing cefazolin unnecessarily.