Plasma donor-derived cell-free DNA kinetics after kidney transplantation using a single tube multiplex PCR assay.
Els M GielisCharlie BeirnaertAmélie DendoovenPieter MeysmanKris LaukensJoachim De SchrijverSteven Van LaeckeWim Van BiesenMarie-Paule EmondsBenedicte Y De WinterJean-Louis BosmansJurgen Del FaveroDaniel AbramowiczKristien J LedeganckPublished in: PloS one (2018)
In conclusion, plasma ddcfDNA fractions decreased exponentially within 10 days after transplantation to a ddcfDNA threshold value of 0.88% or less. To investigate the role of ddcfDNA for rejection monitoring of the graft, future research is needed to determine causes of ddcfDNA% increases above this threshold value.