T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells.

Natalia LaptevaMargaret GilbertIulia DiaconuLisa A RollinsMina Al-SabbaghSwati NaikRobert A KranceTamara TripicManasa HiregangeDarshana RaghavanOlga DakhovaRayne H RouceHao LiuBilal OmerBarbara SavoldoGianpietro DottiConrad Russel CruzKeli SharpeMelissa GatesAaron OrozcoApril DurettElizabeth PachecoAdrian P GeeCarlos Almeida Ramos Helen E HeslopMalcolm K BrennerCliona M Rooney

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Dual T-cell receptor and CAR stimulation can thus potentiate effector cell expansion and CAR-target cell killing, even when infusing low numbers of effector cells without cytoreduction.

Keyphrases

single cell
cell therapy
induced apoptosis
regulatory t cells
dendritic cells
type iii
binding protein
cell proliferation
signaling pathway
wild type