Secretion of IL1 by Dedifferentiated Melanoma Cells Inhibits JAK1-STAT3-Driven Actomyosin Contractility of Lymph Node Fibroblastic Reticular Cells.
Christopher RoveraIlona BerestjukMargaux LecacheurCassandre TavernierSerena DiazziSabrina PisanoMarie IrondelleAude MallavialleJean AlbrenguesCédric GaggioliChristophe A GirardThierry PasseronMarcel DeckertSophie Tartare-DeckertVirginie Prod'hommePublished in: Cancer research (2022)
Communication between dedifferentiated melanoma cells and lymph node fibroblasts reprograms the biomechanical properties of the premetastatic lymph node niche to promote tumor invasion. See related commentary by Lund, p. 1692.