Role of epithelial barrier function in inducing type 2 immunity following early-life viral infection.
Kunyuan TianPrakrati DangarhHaina ZhangChristian L HinesAndrew BushHannah J PybusJames A HarkerClare M LloydReiko J TanakaSejal SaglaniPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2023)
The neonatal murine model demonstrated that recurrent RSV infection in early life alters airway barrier function and promotes type 2 immunity. A causal relationship between airway barrier function and type 2 immunity was suggested using in silico model simulations.
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