Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis.

Malte Christoph RühlemannTimur LiwinskiFemke-Anouska HeinsenCorinna BangRoman ZenouziMartin KummenLouise ThingholmMarie TempelWolfgang LiebTom KarlsenAnsgar LohseJohannes HovGerald DenkFrank LammertMarcin KrawczykChristoph SchrammAndre Franke
Published in: Alimentary pharmacology & therapeutics (2019)
Compared to healthy controls, numerous microbiota alterations are reproducible in PSC patients across geographical regions, clearly pointing towards a microbiota composition that is shaped by the disease itself and not by environmental factors. These reproducibly altered microbial populations might provide future insights into the pathophysiology of PSC.