Concept and benchmarks for assessing narrow-sense validity of genetic risk score values.

Hongjie YuZhuqing ShiYishuo WuChi-Hsiung WangXiaoling LinChelsea PerschonWilliam B IsaacsBrian T HelfandS Lilly ZhengDavid DugganZengnan MoDaru LuJianfeng Xu

Published in: The Prostate (2019)

Performance differed considerably among GRS tests. We recommend that all GRS tests be evaluated using the two benchmarks before clinical implementation for individual risk assessment.

Keyphrases

risk assessment
primary care
healthcare
human health
genome wide
heavy metals
quality improvement
copy number
gene expression
dna methylation