Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication-overuse headache.
Lanfranco PellesiElisa BelleiSimona GuerzoniMaria Michela CainazzoCarlo BaraldiEmanuela MonariLuigi Alberto PiniPublished in: BMC neurology (2019)
L-PGDS, VDBP and APOE had abnormal serum levels in MOH patients, confirming their alteration in some conditions of chronic headache and neuropathic pain. However, they had no relationship with CPTs. The in-depth study of serum proteins represents a promising approach for a better understanding of MOH, as well as the detection of candidate biomarkers for chronic headache or the risks associated with overuse medications.
Keyphrases
- neuropathic pain
- chronic pain
- end stage renal disease
- spinal cord
- spinal cord injury
- chronic kidney disease
- newly diagnosed
- healthcare
- peritoneal dialysis
- prognostic factors
- cognitive decline
- pain management
- high fat diet
- emergency department
- type diabetes
- patient reported outcomes
- adipose tissue
- metabolic syndrome
- drug induced
- skeletal muscle
- mild cognitive impairment
- insulin resistance