Tumor-infiltrating regulatory T cells, CD8/Treg ratio, and cancer stem cells are correlated with lymph node metastasis in patients with early breast cancer.
Luis Alberto Solis-CastilloGina Stella Garcia-RomoAlvaro Diaz-RodriguezDiana Reyes-HernandezElizabeth Tellez-RiveraVictor Hugo Rosales-GarciaAdolfo Rene Mendez-CruzJose Rafael Jimenez-FloresVictor Hugo Villafana-VazquezAlexander Pedroza-GonzálezPublished in: Breast cancer (Tokyo, Japan) (2020)
Early breast cancer has an inflammatory milieu characterized by mDC, Treg, and CSC infiltration. The frequencies of Treg, CSC and CD8/Treg ratio were associated with disease progression. The composition of leukocytes and the presence of CSC in early breast tumors should be considered for the development of new therapeutic approaches.