Immunogenicity of High-Dose Egg-Based, Recombinant, and Cell Culture-Based Influenza Vaccines Compared With Standard-Dose Egg-Based Influenza Vaccine Among Health Care Personnel Aged 18-65 Years in 2019-2020.
Allison L NalewaySara S KimBrendan FlanneryMin Z LevineKempapura MurthySuryaprakash SambharaShivaprakash GangappaLaura J EdwardsSarah BallLauren GrantTnelda ZunieWeiping CaoF Liaini GrossHolly GroomAlicia M FryDanielle HuntZuha JeddyMargarita MishinaMeredith G WesleySarah SpencerMark G ThompsonManjusha GaglaniFatimah S DawoodPublished in: Open forum infectious diseases (2023)
HD-IIV3 did not induce higher antibody responses than SD-IIV4, but, consistent with previous studies, RIV4 was associated with higher postvaccination antibody titers. These findings suggest that recombinant vaccines rather than vaccines with higher egg-based antigen doses may provide improved antibody responses in highly vaccinated populations.