Longitudinal Retinal Changes in MOGAD.
Frederike Cosima OertelElias S SotirchosHanna Gwendolyn ZimmermannSeyedamirhosein MotamediSvenja SpecoviusEva Susanna AsseyerClaudia ChienLawrence CookEleni S VasileiouAngeliki G FilippatouPeter A CalabresiShiv SaidhaLekha PanditAnitha D'CunhaOlivier OutteryckHelene ZephirSean J PittockEoin P FlanaganM Tariq BhattiPaulus S RommerGabriel BstehTobias ZrzavyTania KümpfelOrhan AktasMarius RingelsteinPhilipp AlbrechtIlya AyzenbergThivya PakeerathanBenjamin KnierLilian AlyNasrin AsgariKerstin SoelbergRomain MarignierCaroline Froment TiliketeAlvaro Cobo CalvoPablo VillosladaBernardo Sanchez-DalmauElena H Martinez-LapiscinaSara LlufriuAri J GreenMichael R YeamanTerry J SmithAlexander Ulrich BrandtJohn ChenFriedemann PaulJoachim Havlanull nullPublished in: Annals of neurology (2022)
Our study suggests the absence of attack-independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476-485.