Involvement of Dendritic Cells and Th17 Cells in Induced Tertiary Lymphoid Structures in a Chronic Beryllium Disease Mouse Model.

Alex KleinJanMenno van NimwegenKarolina LemanKe-Xin WenLouis BoonRudi W Hendriks

Published in: Mediators of inflammation (2021)

We generated a translational model of sarcoidosis driven by beryllium and show that DCs and IL-17R signals play a pathophysiological role in CBD development as well as in established CBD in vivo.

Keyphrases

dendritic cells
mouse model
induced apoptosis
cell cycle arrest
immune response
high glucose
drug induced
diabetic rats
high resolution
regulatory t cells
endoplasmic reticulum stress
signaling pathway
cell proliferation
mass spectrometry