A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis.

Jie DengLorne M GolubHsi-Ming LeeVeena RajaFrancis JohnsonAllan KucineWonsae LeeTian-Min XuYing Gu

Published in: Journal of inflammation research (2021)

In conclusion, treating hyperglycemic diabetic rats with CMC2.24 (a tri-ketonic phenylaminocarbonyl curcumin) promotes the resolution of local and systemic inflammation, reduces bone loss, in addition to suppressing collagenolytic MMPs and pro-inflammatory cytokines, suggesting a novel therapeutic strategy for treating periodontitis complicated by other chronic diseases.

Keyphrases

bone loss
diabetic rats
oxidative stress
type diabetes
cardiovascular disease
signaling pathway
high glucose
metabolic syndrome
insulin resistance
endothelial cells
stress induced