Mesenchymal Stem/Stromal Cell Therapy for Radiation-Induced Xerostomia in Previous Head and Neck Cancer Patients: A Phase 2 Randomised, Placebo-Controlled Trial.

Kathrine Kronberg Jakobsen Amanda-Louise Fenger Carlander Tobias Todsen Jacob Melchiors Natasja Paaske Anne Kathrine Østergaard Madsen Simone Kloch Bendtsen Christine Mordhorst Helene Stampe Jens Kastrup Annette Ekblond Mandana Haack-Sørensen Mohammad Farhadi Christian Maare Jeppe Friborg Charlotte Duch Lynggaard Anne Werner Hauge Robin Christensen Christian Grønhøj Larsen Christian von Buchwald

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We could not confirm superiority of the ASC relative to placebo. ASC therapy significantly improved UWS in previous head and neck cancer patients, whereas placebo resulted in an insignificant increase.

Keyphrases

cell therapy
double blind
radiation induced
placebo controlled
stem cells
bone marrow
clinical trial
radiation therapy
nlrp inflammasome
mesenchymal stem cells
phase iii
study protocol
open label
smoking cessation