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Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo.

Pamela LelandHeba DegheidyAshley LeaSteven R BauerRaj K PuriBharat H Joshi
Published in: Clinical and translational medicine (2024)
Taken together, we conclude that the novel scFv-IL-13Rα2 CAR-T cell therapy may offer an effective therapeutic option after designing a careful pre-clinical and clinical study.
Keyphrases
  • cell therapy
  • induced apoptosis
  • endothelial cells
  • stem cells
  • mesenchymal stem cells
  • cell cycle arrest
  • endoplasmic reticulum stress
  • signaling pathway
  • bone marrow
  • double blind
  • cell proliferation