HBV promotes the recruitment of IL-17 secreting T cells via chemokines CCL22 and CCL17.
Ka ZhangYanqiong LiuXiaoan YangHaixia SunXin ShuYeqiong ZhangHong CaoMengdi WuNan LiuYong ZouQihuan XuGang LiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Contact of HBV-transfected cells with MoDCs induces CCL17 and CCL22 chemokine production, which may favour the recruitment of Th17 and Tc17 cells to liver tissue in CHB. Our results reveal the mechanism of IL-17 secreting T cells recruitment to liver tissue and thus provide new immunotherapy targets for CHB patients.
Keyphrases
- induced apoptosis
- liver fibrosis
- liver injury
- hepatitis b virus
- cell cycle arrest
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- endoplasmic reticulum stress
- prognostic factors
- liver failure
- peritoneal dialysis
- cell death
- signaling pathway
- gene expression
- genome wide
- single cell
- cell proliferation
- patient reported outcomes
- pi k akt