Gamma-aminobutyric acid (GABA) levels in the midcingulate cortex and clozapine response in patients with treatment-resistant schizophrenia: A proton magnetic resonance spectroscopy ( 1 H-MRS) study.
Fumihiko UenoShinichiro NakajimaYusuke IwataShiori HondaEdgardo Torres-CarmonaWanna MarSakiko TsugawaPeter TruongEric PlitmanYoshihiro NodaMasaru MimuraNapapon SailasutaMark MikkelsenRichard A E EddenVincenzo De LucaGary RemingtonPhilip GerretsenAriel Graff-GuerreroPublished in: Psychiatry and clinical neurosciences (2022)
Our study is the first to report elevated GABA levels in the MCC in patients with schizophrenia resistant to clozapine treatment compared with those responsive to clozapine. Longitudinal studies are required to evaluate if GABA levels are a suitable biomarker to predict clozapine resistance.