Characterization of Cell-free DNA Size Distribution in Osteosarcoma Patients.

Sasimol Udomruk Areerak Phanphaisarn Thanat Kanthawang Apiwat Sangphukieo Songphon Sutthitthasakul Siripong Tongjai Pimpisa Teeyakasem Patcharawadee Thongkumkoon Santhasiri Orrapin Sutpirat Moonmuang Jeerawan Klangjorhor Arnat Pasena Pathacha Suksakit Sivamoke Dissook Pitithat Puranachot Jongkolnee Settakorn Tonapha Pusadee Dumneoensun Pruksakorn Parunya Chaiyawat

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

This finding demonstrated the potential of cfDNA size profiling in the stratification of poor prognostic patients with osteosarcoma. The short fragments of cfDNA are a promising source for boosting the detection of significant mutations in osteosarcoma.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
patient reported
loop mediated isothermal amplification