Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene.
Kathryn P BurdonRhys D FogartyWeiyong ShenSotoodeh AbharyGeorgia KaidonisBinoy AppukuttanAlex W HewittShiwani SharmaMark DaniellRohan W EssexJohn H ChangSonja KlebeStewart R LakeBishwanath PalAlicia JenkinsGowthaman GovindarjanPeriasamy SundaresanEcosse L LamoureuxKim RamasamyMaria PefkianakiPhilip G HykinNikolai PetrovskyMatthew A BrownMark C GilliesJamie E CraigPublished in: Diabetologia (2015)
Genetic variation near GRB2 on chromosome 17q25.1 is associated with sight-threatening diabetic retinopathy. Several genes in this region are promising candidates and in particular GRB2 is upregulated during retinal stress and neovascularisation.