Comparison of Coccidioidal Complement Fixation and Quantitative Immunodiffusion Serology at a Reference Laboratory.

The incidence of coccidioidomycosis continues to increase. The diagnosis frequently relies on non-invasive diagnostic testing with immunodiffusion and complement fixation (CF) testing the current gold-standard. A direct comparison of quantitative immunodiffusion and CF for IgG antibodies has not been previously reported. In a comparison of 368 samples, there was close concordance observed (360/368 = 97.8%) (p-value < .001). These tests can be considerable interchangeable in the reference laboratory setting.