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Time-resolved microfluidics unravels individual cellular fates during double-strand break repair.

Nadia Vertti-QuinteroEthan LevienLucie PoggiAriel AmirGuy-Franck RichardCharles N Baroud
Published in: BMC biology (2022)
Our analysis paves the way to a significant advance in understanding the complex molecular mechanism of DSB repair, with potential implications beyond yeast cell biology. This multiscale and multidisciplinary approach more generally allows unique insights into the relation between in vivo microscopic processes within each cell and their impact on the population dynamics, which were inaccessible by previous approaches using molecular genetics tools alone.
Keyphrases
  • single cell
  • cell therapy
  • quality improvement
  • risk assessment
  • bone marrow
  • human health
  • cell wall