Anti-inflammatory effects of apocynin on dextran sulfate sodium-induced mouse colitis model.
Young-Jae HwangSeung-Joo NamWanjoo ChunSong In KimSung Chul ParkChang Don KangSung Joon LeePublished in: PloS one (2019)
Apocynin showed significant anti-inflammatory efficacy against chemically induced colonic inflammation. This study also revealed the unique action of apocynin compared to the currently prescribed drug, sulfasalazine. Given its excellent safety profile and potent efficacy with novel action mechanism, apocynin can be a new therapeutic molecule for the IBD treatment, which can be added to the currently available drugs.