Intestinal toll-like receptor 4 knockout alters the functional capacity of the gut microbiome following irinotecan treatment.
Kate R SecombeElise E CrameJanine S Y TamHannah R WardillRachel J GibsonJanet K CollerJoanne M BowenPublished in: Cancer chemotherapy and pharmacology (2021)
Tlr4ΔIEC and WT had no baseline compositional microbiome differences, but functional differences at baseline and following irinotecan. FMT altered some aspects of irinotecan-induced gastrointestinal toxicity.