Early increase of circulating transitional B cells and autoantibodies to joint-related proteins in patients with metastatic melanoma developing checkpoint inhibitor-induced inflammatory arthritis.

Mariele GattoSara BjurstenCharlotte A JonssonMonica Leu AgeliiCaroline JonellSarah McGrathErik LönnblomOuti Sareila Rikard HolmdahlAnna RudinMax LevinInger Gjertsson

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Development of ICI-IA is accompanied by an increase in transitional B cells and by production of autoantibodies to joint-related proteins. Monitoring of B cell-driven abnormalities upon ICI treatment may help earlier recognition of ICI-IA. This article is protected by copyright. All rights reserved.

Keyphrases

systemic lupus erythematosus
rheumatoid arthritis
dna damage
oxidative stress
high glucose
drug induced
diabetic rats
cell cycle
stress induced