IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.

Joris RamsteinCaroline E BroosLaura J SimpsonK Mark AnselSara A SunMelissa E HoPrescott G WoodruffNirav R BhaktaLaura ChristianChristine P NguyenBobby J AntalekBryan S BennRudi W HendriksBernt van den BlinkMirjam KoolLaura L Koth

Published in: American journal of respiratory and critical care medicine (2017)

Combined use of surface markers and functional assays to study CD4(+) T cells in sarcoidosis revealed a marked expansion of Th17.1 cells that only produce IFN-γ. These results suggest that Th17.1 cells could be misclassified as Th1 cells and may be the predominant producer of IFN-γ in pulmonary sarcoidosis, challenging the Th1 paradigm of pathogenesis.

Keyphrases

induced apoptosis
cell cycle arrest
dendritic cells
immune response
cell death
signaling pathway
regulatory t cells
oxidative stress