Severe Obstructive Sleep Apnea Is Associated with Alterations in the Nasal Microbiome and an Increase in Inflammation.

Benjamin G WuImran SulaimanJing WangNan ShenJose C ClementeYonghua LiRobert J LaumbachShou-En LuIris UdasinOanh Le-HoangAlan PerezShahnaz AlimokhtariKathleen BlackMichael PlietzAkosua TwumasiHaley SandersPatrick MalechaBianca KapoorBenjamin D ScaglioneAnbang WangCameron BlazoskiMichael D WeidenDavid M RapoportDenise HarrisonNishay ChitkaraEugenio VicenteJosé M MarinJag SunderramIndu AyappaLeopoldo N Segal

Published in: American journal of respiratory and critical care medicine (2019)

We demonstrate that the presence of an altered microbiome in severe OSA is associated with inflammatory markers. Further experimental approaches to explore causal links are needed.

Keyphrases

obstructive sleep apnea
positive airway pressure
early onset
oxidative stress
drug induced
sleep apnea