Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.
Amanda Z ZucolotoMarília F ManchopeLarrisa Staurengo-FerrariJosé C Alves-FilhoThiago M CunhaMaísa M AntunesGustavo B MenezesFernando Q CunhaRubia CasagrandeWaldiceu Aparecido VerriPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)
Probucol presents analgesic and anti-inflammatory activities by employing mechanisms other than its antioxidant properties. These mechanisms involve targeting of pro-inflammatory cytokines and NF-кB activation.