Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal Cancer.

Andreana N Holowatyj Wanqing Wen Timothy Gibbs Hannah M Seagle Samantha R Keller Digna R Velez Edwards Mary Kay Washington Cathy Eng José Perea Quan Long Xingyi Guo

Published in: Cancer discovery (2023)

NHBs, but not APIs, with early-onset nonhypermutated colorectal cancer had higher adjusted tumor mutation rates versus NHWs. Differences for FLT4, FBXW7, RNF43, LRP1B, APC, PIK3CA, and ATRX mutation rates between racial/ethnic groups and EP300, KRAS, AXIN2, WRN, BRAF, and LRP1B mutation rates by sex were observed in tumors of young patients. See related commentary by Shen et al., p. 530 . This article is highlighted in the In This Issue feature, p. 517.

Keyphrases

early onset
late onset
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
machine learning
prognostic factors
papillary thyroid
peritoneal dialysis
wild type
tyrosine kinase
squamous cell
copy number
young adults
gene expression
middle aged
dna damage
lymph node metastasis