One-Step Conversion of Potassium Organotrifluoroborates to Metal Organoborohydrides.

Christopher M BatemanHailey BealJoshua E BarkerBrena L ThompsonDrake DonovanBradley J GrantJesse ShooterJordan H ArakawaSpencer JohnsonCaleb J AllenJames L YatesRyota KatoColby W K TinsleyLev N ZakharovEric R Abbey

Published in: Organic letters (2018)

This letter describes the one-step conversion of heteroatom-substituted potassium organotrifluoroborates (KRBF3) to metal monoorganoborohydrides (MRBH3) using alkali metal aluminum hydrides. The method tolerates a variety of functional groups, expanding MRBH3 diversity. Hydride removal with Me3SiCl in the presence of dimethylaminopyridine (DMAP) affords the organoborane·DMAP (RBH2·DMAP) adducts.

Keyphrases

molecular docking