Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure.
Olav L SchjørringThomas Lass KlitgaardAnders PernerJørn WetterslevTheis LangeMartin SiegemundMinna BäcklundFrederik KeusJon H LaakeMatthew MorganKatrin M ThormarSøren A RosborgJannie BisgaardAnnette E S ErntgaardAnne-Sofie H LynnerupRasmus L PedersenElena CrescioliTheis C GielstrupMeike T BehzadiLone M PoulsenStine EstrupJens P LaigaardCheme AndersenCamilla B MortensenBjörn A BrandJonathan WhiteInge-Lise JarnvigMorten H MøllerLars QuistMorten H BestleMartin Schønemann-LundMaj K KamperMathias HindborgAlexa HollingerCaroline E GebhardNúria ZellwegerChristian S MeyhoffMathias HjortLaura K BechThorbjørn GrøfteHelle BundgaardLars H M ØstergaardMaria A ThyøThomas HildebrandtBülent UsluChristoffer G SøllingNette Møller-NielsenAnne C BrøchnerMorten BorupMarjatta OkkonenWillem DieperinkUlf G PedersenAnne S AndreasenLone BuusTayyba N AslamRobert R WindingJoerg C SchefoldStine B ThorupSusanne A IversenJanus EngstrømMaj-Brit N KjærBodil Steen Rasmussennull nullPublished in: The New England journal of medicine (2021)
Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days. (Funded by the Innovation Fund Denmark and others; HOT-ICU ClinicalTrials.gov number, NCT03174002.).