Epilepsy in families: Age at onset is a familial trait, independent of syndrome.

Colin A EllisLeonid ChurilovMichael P EpsteinSharon X XieSusannah T BellowsRuth Ottman Samuel Frank Berkovicnull null

Published in: Annals of neurology (2019)

Age at seizure onset is an independent familial trait, and may have genetic determinants distinct from the determinants of particular epilepsy syndromes. Younger onsets in successive generations can be explained in part by sampling bias, but the presence of genetic anticipation cannot be excluded. ANN NEUROL 2019.

Keyphrases

genome wide
early onset
dna methylation
temporal lobe epilepsy
copy number
case report
gene expression