Macrophage Migration Inhibitory Factor Promotes Thromboinflammation and Predicts Fast Progression of Aortic Stenosis.

Karin Anne Lydia MuellerCarolin LangnauTobias Harm Manuel Sigle Kristina Mott Michal Droppa Oliver Borst Anne-Katrin RohlfingSarah GekelerManina Günter Nora GöbelUlrich F W FrankeMedhat RadwanChristian Schlensak Henrik Janning Sophia Scheuermann Christian Martin Seitz Dominik RathKlaus-Peter KreisselmeierTatsiana CastorIris Irmgard MuellerHarald SchulzeStella E AutenriethMeinrad Paul Gawaz

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Our findings suggest a key role for platelet-derived MIF and its interplay with circulating and valve resident monocytes/macrophages in local and systemic thromboinflammation during accelerated AS. MIF-based biomarkers predict an accelerated course of AS and represent a novel pharmacological target to attenuate progression of AS.

Keyphrases

aortic stenosis
transcatheter aortic valve replacement
aortic valve
ejection fraction
aortic valve replacement
transcatheter aortic valve implantation
left ventricular
coronary artery disease
adipose tissue
patient safety
dendritic cells
quality improvement