Highly Efficient Electrosynthesis of Nitric Oxide for Biomedical Applications.
Jing JinJunjie MaoWenjie WuYing JiangWenjie MaPing YuLanqun MaoPublished in: Angewandte Chemie (International ed. in English) (2022)
Nitric oxide (NO) constitutes one of the most versatile therapeutics for biomedical applications. The efficient and on-demand NO generation essentially dictates its concentration dependent therapeutic activity. Here, we report an electrochemical system employing a rationally designed single-iron atom based biomimetic catalyst (i.e., Fe SAC), for high-efficient and controlled NO generation. The Fe SAC shows superior catalytic ability in electrochemical reduction of nitrite, with maximal NO generation rate achieving 2.1 μM (min μg) -1 . Theoretical studies suggest the significant decrease of Gibbs-free energy of NO 2 - adsorption on single-iron atom accounts for its high catalytic efficiency. Moreover, ample amount of NO can be controllably generated in a potential dependent manner. For antibacterial application, the generated NO overwhelmingly disrupts both gram-negative and gram-positive strains, highlighting a great promise to expedite NO research in both basic and applied sciences.
Keyphrases
- nitric oxide
- gram negative
- highly efficient
- multidrug resistant
- ionic liquid
- nitric oxide synthase
- gold nanoparticles
- molecular dynamics
- metal organic framework
- hydrogen peroxide
- electron transfer
- escherichia coli
- aqueous solution
- molecularly imprinted
- label free
- visible light
- crystal structure
- big data
- blood pressure
- reduced graphene oxide
- artificial intelligence
- silver nanoparticles
- deep learning
- climate change
- wound healing