Presynaptic membrane protein dysfunction occurs prior to neurodegeneration and predicts faster cognitive decline.

Guoyu LanAnqi LiZhen LiuShaohua MaTengfei Guonull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

These findings suggest that presynaptic loss may occur prior to neurodegeneration, highlighting the importance of lowing tau aggregation and tau-related synaptic dysfunction in elderly adults and AD patients.

Keyphrases

cognitive decline
end stage renal disease
mild cognitive impairment
ejection fraction
oxidative stress
newly diagnosed
chronic kidney disease
cerebrospinal fluid
peritoneal dialysis
prognostic factors
middle aged
patient reported outcomes
prefrontal cortex