Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs.
Giulia Dell'OmoDaniela CrescentiCristina VantaggiatoChiara ParraviciniAurora Paola BorroniNicoletta RizziMariangela GarofaloAndrea PintoCamilla RecordatiEugenio ScanzianiFabio Domenico BassiGiancarlo PruneriPaola ContiIvano EberiniAdriana MaggiPaolo CianaPublished in: British journal of cancer (2019)
Our study, for the first-time, links NSAID chemopreventive activity with direct SIRT1 inhibition and activation of the p53/p21 anti-oncogenic pathway, suggesting a novel strategy for the design of tumour-protective drugs.