Clinical utility of custom-designed NGS panel testing in pediatric tumors.
Lea F SurreySuzanne P MacFarlandFengqi ChangKajia CaoKomal S RathiGozde T AkgumusDaniel GalloFumin LinAdam GleasonPichai RamanRichard AplencRochelle BagatellJane MinturnYael MosseMariarita SantiSarah K TasianAngela J WaandersMahdi SarmadyJohn M MarisStephen P HungerMarilyn M LiPublished in: Genome medicine (2019)
Use of somatic NGS panel testing resulted in a significant impact on clinical care, including diagnosis, prognosis, and treatment planning in 78.7% of pediatric patients tested in our institution. Somatic NGS tumor testing should be implemented as part of the routine diagnostic workup of newly diagnosed and relapsed pediatric cancer patients.