Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis.
Antonia RuJia SunSunil K PanchalThor FriisSunderajhan SekarRoss CrawfordLindsay BrownYin XiaoIndira PrasadamPublished in: PloS one (2017)
Our study demonstrate a strong association between obesity and a dynamic immune response locally within synovial tissues. Furthermore, we have also identified synovial resident macrophages to play a vital role in the inflammation caused by the HCHF diet. Therefore, future therapeutic strategies targeted at the synovial macrophage phenotype may be the key to break the link between obesity and OA.
Keyphrases
- metabolic syndrome
- insulin resistance
- weight loss
- high fat diet induced
- immune response
- adipose tissue
- type diabetes
- weight gain
- uric acid
- knee osteoarthritis
- gene expression
- physical activity
- rheumatoid arthritis
- cardiovascular risk factors
- patient safety
- cancer therapy
- dendritic cells
- body mass index
- quality improvement
- drug delivery