Long-Term Persistence of Spike Antibody and Predictive Modeling of Antibody Dynamics Following Infection with SARS-CoV-2.
Louis GrandjeanAnja SasoArturo Torres OrtizTanya LamJames HatcherRosie ThistlethwayteMark HarrisTimothy BestMarina JohnsonHelen R WagstaffeElizabeth RalphAnnabelle MaiCaroline ColijnJudith BreuerMatthew BucklandKimberly GilmourDavid Goldblattnull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
The Co-STAR's study data presented here provides evidence for long-term persistence of neutralizing S-antibodies. This has important implications for the duration of functional immunity following SARS-CoV-2 infection. In contrast, the rapid decay of N-antibodies must be considered in future seroprevalence studies and public health decision-making. This is the first study to establish a mathematical framework capable of predicting long-term humoral dynamics following SARS-CoV-2 infection.