May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia.
Javier Molina-CerrilloJuan Marquet-PalomanesTeresa Alonso GordoaJavier López-JiménezEnrique GrandePublished in: Healthcare (Basel, Switzerland) (2021)
COVID-19 is affecting many countries all around the world. Unfortunately, no treatment has already been approved for the management of patients infected by SARS-CoV-2. It seems that SARS-CoV-2 can induce the activation of an exaggerated immune response against itself according to different mechanisms that are not really well known. Inflammatory interleukins, such as IL-6 among others, play a central role in this uncontrolled immune response. There is a strong rational under ibrutinib use in in the treatment of immune-based diseases, such a as GVHD or RA. Ibrutinib achieves a reduction in the production of TNFα, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. We present our clinical experience about ibrutinib use in ARDS secondary to SARS-CoV-2 in a patient with chronic lymphocytic leukemia (CLL).
Keyphrases
- chronic lymphocytic leukemia
- sars cov
- immune response
- respiratory syndrome coronavirus
- rheumatoid arthritis
- dendritic cells
- case report
- combination therapy
- endothelial cells
- risk factors
- squamous cell carcinoma
- intensive care unit
- toll like receptor
- acute lymphoblastic leukemia
- protein protein
- disease activity
- acute myeloid leukemia
- peripheral blood
- systemic lupus erythematosus