Effect of perioperative intravenous ibuprofen versus acetaminophen on postoperative opioid consumption and pain after general anesthesia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.

Sung Hye KimHyun KangIn-Jung JunHye Won ParkByung Hoon YooYun-Hee LimKye-Min Kim

Published in: Korean journal of anesthesiology (2024)

Perioperative IV ibuprofen reduced 24 h opioid consumption and pain severity up to 12 h postoperatively compared to acetaminophen. Additional research is required to assess pain intensity beyond 12 h and side effects.

Keyphrases

chronic pain
pain management
patients undergoing
neuropathic pain
postoperative pain
cardiac surgery
clinical trial
high dose
study protocol
spinal cord injury
phase iii
high intensity
phase ii
spinal cord
data analysis