Effect of diuretics on plasma aldosterone and potassium in primary hypertension: A systematic review and meta-analysis.
Ryan John McnallyBushra FarukhPhilip J ChowienczykLuca FacontiPublished in: British journal of clinical pharmacology (2021)
In RCT of diuretic therapy in hypertension, there is an increase in PA with all classes of diuretic and no significant between-class heterogeneity. Change in PA is not related with potassium but correlates with the change in BP in subjects untreated with another antihypertensive medication.