Nuclear Factor Erythroid 2-Related Factor 2 Activating Triterpenoid Saponins from Camellia japonica Roots.
Kiwon KoLilik D WahyudiYong-Soo KwonJung-Hwan KimHeejung YangPublished in: Journal of natural products (2018)
Oxidative stress due to the presence of excess reactive oxygen species may cause cancers, aging, and many other conditions. Nuclear factor erythroid 2-related factor 2 (Nrf2) may control abnormal oxidative stress as a transcription factor by inducing antioxidant-related genes via antioxidant response elements (AREs) in the gene promoters. The 11 triterpenoid saponins (1-11) isolated from Camellia japonica roots were tested for ARE-luciferase activity and Nrf2 accumulation in human keratinocytes (HaCaT cells). The ARE-luciferase activity was significantly increased by compounds 1-11 (25 μM) as a result of nuclear Nrf2 accumulation in the cells. Thus, these compounds may contribute to the induction of Nrf2 activity against oxidative damage in cells.
Keyphrases
- oxidative stress
- induced apoptosis
- nuclear factor
- toll like receptor
- cell cycle arrest
- transcription factor
- dna damage
- ischemia reperfusion injury
- diabetic rats
- endoplasmic reticulum stress
- signaling pathway
- reactive oxygen species
- immune response
- gene expression
- cell death
- cell proliferation
- genome wide
- dna methylation
- heat shock
- copy number
- heat stress