Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis.

Jiao FengChengfen WangTong LiuJingjing LiLiwei WuQiang YuSainan LiYuting ZhouJie ZhangJiaojiao ChenJie JiKan ChenYuqing MaoFan WangWeiqi DaiXiaoming FanJianye WuChuan-Yong Guo

Published in: Journal of cellular and molecular medicine (2019)

PB2 inhibited the Hh pathway to suppress the activation, ECM production and angiogenesis of HSCs, therefore reverses the progression of liver fibrosis in vivo and in vitro.

Keyphrases

liver fibrosis
endothelial cells
induced apoptosis
vascular endothelial growth factor
cell cycle arrest
heavy metals
signaling pathway
oxidative stress
endoplasmic reticulum stress
risk assessment
cell death