Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial.

Tobias H BecherAndreas MeiserUlf GuentherMartin BellgardtJan WallenbornKlaus KogelmannHendrik BrachtAndreas FalthauserJonas NilssonPeter SackeyPatrick Kellner

Published in: Annals of intensive care (2022)

In patients with AHRF, inhaled sedation with isoflurane for a duration of up to 48 h did not lead to improved oxygenation in comparison to intravenous sedation with propofol. Trial registration The main study was registered in the European Medicines Agency's EU Clinical Trial register (EudraCT), 2016-004551-67, before including the first patient. The present substudy was registered at German Clinical Trials Register (DRKS, ID: DRKS00018959) on January 7th, 2020, before opening the main study data base and obtaining access to study results.

Keyphrases

clinical trial
respiratory failure
mechanical ventilation
study protocol
phase ii
machine learning
cystic fibrosis
case report
big data
artificial intelligence
placebo controlled
clinical evaluation