Ginsenoside Rg1 ameliorates cerebral ischemia-reperfusion injury by regulating Pink1/ Parkin-mediated mitochondrial autophagy and inhibiting microglia NLRP3 activation.

Changbai SuiYing LiuJun JiangJianhua TangLing YuGuoying Lv

Published in: Brain research bulletin (2024)

Our results suggest that ginsenoside Rg1 can ameliorate cerebral ischemia-reperfusion injury by modulating Pink1/ Parkin-mediated mitochondrial autophagy in microglia and inhibiting microglial NLRP3 activation.

Keyphrases

oxidative stress
signaling pathway
ischemia reperfusion injury
inflammatory response
neuropathic pain
subarachnoid hemorrhage
cell death
endoplasmic reticulum stress
nlrp inflammasome
lps induced
mouse model
spinal cord
spinal cord injury
cerebral blood flow